期刊
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
卷 6, 期 4, 页码 441-451出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/A:1014739131690
关键词
adhesion; autotaxin; BRMS1; chemokine; E-cadherin; FasL; Kai1; KiSS1; maspin; metastasis promoter gene; metastasis activator gene; metastasis suppressor gene; MKK4; Nm23; osteonectin; osteopontin; proteinase; RhoC; TIMPs
资金
- NCI NIH HHS [CA62168, CA90991, CA88728] Funding Source: Medline
Once cancer cells have spread and formed secondary masses, breast cancers are largely incurable even with state-of-the-art medicine. To improve diagnosis and therapy, better markers are needed to distinguish cells which have a high probability for causing clinically relevant. macroscopic metastasis. In this review. we summarize the several genes that regulate breast cancer metastasis. Two categories of genes are presented-metastasis activator (ras, MEK1, mta1, proteinases, adhesion molecules, chemoattractants/receptors, autotaxin, PKC, S100A4, RhoC, osteopontin) and metastasis suppressor (Nm23, E-cadherin, TIMPs, KiSS1, Kai1, Maspin, MKK4, BRMS1). While the mechanisms of action for most of these genes are not fully elucidated, some clues are emerging and are presented.
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