期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 119, 期 2, 页码 205-213出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(01)00394-0
关键词
experimental allergic encephalomyelitis; multiple sclerosis; cuprizone; piperonyl butoxide; T-cells; demyelination; SJL mice; graft vs. host disease
资金
- NICHD NIH HHS [HD 02528] Funding Source: Medline
Multiple sclerosis (MS) and its animal model, experimental allergic encephalomyelitis (EAE), are autoimmune demyelinating diseases with autoreactive T-cells acting as important mediators of pathogenesis. Cuprizone, a copper chelator, and piperonyl butoxide (PBO), a pesticide synergist, are implicated to inhibit T-cell activation and function. The purpose of this study was to assess whether either of these agents would suppress PLP-peptide-induced EAE in the SJL mouse. Indeed, treatment with cuprizone beginning 1 week prior to disease induction, and PBO administration from days 1 to 9 of EAE, significantly attenuated EAE clinical severity. Furthermore, both agents decreased blood CD4(+)/CD8(+) ratios, and reduced signs of chronic graft vs. host disease (GVHD) indicating attenuation of an immune T-cell response. These results suggest that cuprizone and PBO suppress EAE and use of these agents will provide insights into the mechanisms of T-cell mediated diseases. (C) 2001 Elsevier Science B.V. All rights reserved.
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