期刊
MOLECULAR PHYLOGENETICS AND EVOLUTION
卷 21, 期 1, 页码 93-102出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/mpev.2001.0994
关键词
nuclear receptor; Cnidaria; coral; Acropora; COUPTF; tailless; HNF4
We have amplified and sequenced PCR products derived from 10 nuclear receptor (NR) genes from the anthozoan cnidarian Acropora millepora, including five products corresponding to genes not previously reported from the phylum Cnidaria. cDNAs corresponding to seven of these products were sequenced and at least three encode full-length proteins, increasing the number of complete cnidarian NR coding sequences from one to four. All clear orthologs of Acropora NRs either lack an activation domain or lack a known ligand, consistent with the idea that the ancestral nuclear receptor was without a ligand. Phylogenetic analyses indicate that most, and possibly all, presently identified cnidarian NRs are members of NR subfamily 2, suggesting that the common ancestor of all known nuclear receptors most resembled members of this subfamily. (C) 2001 Academic Press.
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