期刊
EXPERT OPINION ON THERAPEUTIC PATENTS
卷 11, 期 10, 页码 1523-1531出版社
ASHLEY PUBLICATIONS LTD
DOI: 10.1517/13543776.11.10.1523
关键词
gamma-aminobutyric acid(A) (GABA(A)); androgen; CNS; receptors; glucocorticoid; glutamate (NMDA) receptors; mineralocorticoid; neuroactive steroid; neurosteroid; oestrogen; progestin; steroid
The importance of steroids for modulation of the CNS is now better understood but it is still in its infancy compared with the knowledge that has been accumulated on their endocrine effects. The structural diversity of steroids that exert CNS activity is broad and they modulate their effects, not only via classical steroid receptors (oestrogen, androgen, progestin, glucocorticoid and mineralocorticoid) but also via ion channels, particularly GABAA receptors and glutamate (NMDA) receptors. This review illustrates the therapeutic potential of steroids for treatment of CNS disorders by covering publications and patent literature since 1995.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据