期刊
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
卷 18, 期 4, 页码 329-334出版社
WILEY
DOI: 10.1046/j.0960-7692.2001.00542.x
关键词
fetal Doppler; high altitude; hypoxia; ultrasound
Objectives To determine impedance and velocity characteristics of the fetal circulation using Doppler ultrasound, at extremely high altitude (4300 m) in the Peruvian Andes compared to an ethnically similar population at sea level. Methods This was a cross-sectional study of 196 women resident at high altitude (Cerro de Pasco, 4300 m above sea level) and 196 women resident at sea level (Lima) with normal singleton pregnancies. Pulsatility index (PI), maximum velocity (V-max) and minimum velocity (V-min) in the umbilical artery, the descending aorta, the middle cerebral artery and the ductus venosus were compared between the two populations using fractional polynomial regression analysis. Results The PI was higher at high altitude than at sea level in the umbilical artery (regression coefficient= 0. 112, P < 0.001), and not significantly different in the descending aorta, middle cerebral artery, and ductus venosus. V-max was lower at high altitude than at sea level in all three arterial vessels assessed; V-min was lower in two: the umbilical artery and the descending aorta. The high-altitude/sea-level ratios for umbilical artery V-max and V-min were 0.93 and 0.82, respectively (P < 0.001 for each), the ratios for descending aorta V-max and V-min were 0.93 and 0.89, respectively (P = 0.003 and P < 0.001, respectively), and the regression coefficient for the middle cerebral artery V-max was -2.844 (P = 0.003). There was no significant difference in the middle cerebral artery V-min or in the ductus venosus V-max and V-min. Conclusions Despite the lower ambient oxygen at high altitude and an increase in umbilical artery PI, the fetal circulation does not exhibit a 'brain sparing effect'. This and the overall decrease in blood flow velocities in the fetal circulation at high altitude mail be due to the increased fetal hematocrit, which will result in increased blood viscosity.
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