期刊
BEHAVIOR GENETICS
卷 43, 期 5, 页码 374-385出版社
SPRINGER
DOI: 10.1007/s10519-013-9599-5
关键词
Longitudinal; Twin study; Tobacco; Cannabis; Alcohol; Drug dependence
资金
- NIMH [MH019927, MH063207]
- NICHD [MH063207, HD010333, HD 010333]
- NIDA [DA011015, DA015522]
- NIAAA [AA021113]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD010333] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH063207, R56MH063207, T32MH019927] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [K01AA021113, T32AA007464] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA021913, P60DA011015, R01DA015522] Funding Source: NIH RePORTER
This study investigated the stability of genetic and environmental effects on the common liability to alcohol, tobacco, and cannabis dependence across adolescence and young adulthood. DSM-IV symptom counts from 2,361 adolescents were obtained using a structured diagnostic interview. Several sex-limited longitudinal common pathway models were used to examine gender differences in the magnitude of additive genetic (A), shared environment, and non-shared environmental effects over time. Model fitting indicated limited gender differences. Among older adolescents (i.e., age > 14), the heritability of the latent trait was estimated at 0.43 (0.05, 0.94) during the first wave and 0.63 (0.21, 0.83) during the second wave of assessment. A common genetic factor could account for genetic influences at both assessments, as well as the majority of the stability of SAV over time [rA = 1.00 (0.55, 1.00)]. These results suggest that early genetic factors continue to play a key role at later developmental stages.
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