期刊
BEHAVIOR GENETICS
卷 42, 期 5, 页码 830-844出版社
SPRINGER
DOI: 10.1007/s10519-012-9543-0
关键词
Anxiety; Cdh23(ahl) mutation; Comparative method; Experimental evolution; Exploration; Inbred strains
资金
- Natural Sciences and Engineering Research Council of Canada
- NSF Grant [IOS-1121273]
Voluntary wheel running and open-field behavior are probably the two most widely used measures of locomotion in laboratory rodents. We tested whether these two behaviors are correlated in mice using two approaches: the phylogenetic comparative method using inbred strains of mice and an ongoing artificial selection experiment on voluntary wheel running. After taking into account the measurement error and phylogenetic relationships among inbred strains, we obtained a significant positive correlation between distance run on wheels and distance moved in the open-field for both sexes. Thigmotaxis was negatively correlated with distance run on wheels in females but not in males. By contrast, mice from four replicate lines bred for high wheel running did not differ in either distance covered or thigmotaxis in the open field as compared with mice from four non-selected control lines. Overall, results obtained in the selection experiment were generally opposite to those observed among inbred strains. Possible reasons for this discrepancy are discussed.
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