期刊
BEHAVIOR GENETICS
卷 41, 期 5, 页码 691-699出版社
SPRINGER
DOI: 10.1007/s10519-011-9449-2
关键词
Ageing; Fibrinogen; Cognition; Single nucleotide polymorphism; Diabetes
资金
- Wellcome Trust
- Chest Heart and Stroke Scotland
- British Heart Foundation
- Chief Scientist Office, Scotland
- Research Into Ageing
- Help the Aged
- Medical Research Council
- REM
- BBSRC
- EPSRC
- ESRC
- MRC
- BBSRC [BB/F019394/1] Funding Source: UKRI
- MRC [G0800803, G0500877, G0700704] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: researchfish
- Medical Research Council [G0500877, G0700704, G0800803, G0700704B] Funding Source: researchfish
There is increasing evidence to suggest that elevated plasma levels of fibrinogen are associated with late-life cognitive performance. This study tested the association of single nucleotide polymorphisms in the fibrinogen alpha (FGA) and beta (FGB) genes with cognitive performance. Data were analysed from three community-dwelling populations of older persons (> 50 years) in central Scotland: the Aspirin for Asymptomatic Atherosclerosis (AAA) Trial (n = 2,091), the Edinburgh Type 2 Diabetes Study (ET2DS, n = 1,066), and the Lothian Birth Cohort 1936 (LBC1936, n = 1,091). Cognition was assessed using a battery of five, seven, and four psychometric tests, respectively. This information was used to derive a general cognitive factor. Weakly significant associations were found between the rs4220 (FGB), and rs2227412 (FGB) SNPs and a single test of cognitive performance in the AAA Trial (p < 0.05). These findings did not replicate in the LBC1936 or ET2DS cohorts, except for the rs2227412 SNP, which was significantly associated with the general cognitive factor in the ET2DS (p = 3.3 x 10(-4)). A summary term that combined results from all three studies suggested that the rs2227412 genotype associated with reduced cognitive ability also associated with higher plasma fibrinogen levels. These findings suggest a tentative role for fibrinogen as a determinant of late-life cognitive performance and justify further attempts at replication in older persons.
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