期刊
CURRENT OPINION IN MICROBIOLOGY
卷 4, 期 5, 页码 586-594出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S1369-5274(00)00255-1
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- NIAID NIH HHS [R01-AI43917] Funding Source: Medline
- NIGMS NIH HHS [R01-GM53158] Funding Source: Medline
'Adaptive' or 'stationary-phase' mutation is a collection of stress responses promoting mutations, some of which are advantageous. In 2000 and 2001, in Escherichia coli, adaptive gene amplification was documented, and a parallel adaptive point-mutation mechanism was linked to the error-prone DNA polymerase, DinB (pol IV). We suggest that DinB homologues may contribute to adaptive strategies of pathogens, including antigenic variation.
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