期刊
EXPERIMENTAL AND MOLECULAR PATHOLOGY
卷 71, 期 2, 页码 171-178出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/exmp.2001.2386
关键词
Whn; Hfh11(nu); baldness; skin
类别
The original nude mouse mutation has proven to be an incredibly valuable biomedical tool since its discovery in 1966. Initially its value was as a tool to study the immune system. The immunodeficiency in this mutant mouse made nude mice valuable as hosts for xenografts, primarily for cancer research. More recently, the most obvious clinical feature of this mutant mouse, lack of hair, has been capitalized on to define the role of Foxn1 in normal and pathological skin and hair follicle physiology. (C) 2001 Academic Press.
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