期刊
MEDICAL AND PEDIATRIC ONCOLOGY
卷 37, 期 4, 页码 393-399出版社
WILEY-LISS
DOI: 10.1002/mpo.1216
关键词
handwriting; children with cancer; leukemia; vincristine neuropathy
Background. Children treated for acute lymphoblastic leukemia (ALL) often complain about handwriting problems. Procedure. Using a computerized writing task, we have prospectively studied the processes necessary for the production of handwriting movements in I I children (5-12 years old) during treatment for ALL. Children were tested at time points closely related to the vincristine administration. Results and Conclusions. Children treated for ALL drew slower, with longer pause durations and increased drawing pressure. Children were able to overcome the problems, except for a consistently increased drawing pressure. This increased drawing pressure may be an attempt of the children to obtain sufficient kinesthetic information and thus can be seen as an adequate adaptation mechanism in case of peripheral neuropathy due to the neurotoxic effects of vincristine. However, neurotoxic effects of other cytostatic drugs cannot be excluded. Med Pediatr Oncol 2001;37:393-399. (C) 2001 Wiley-Liss, Inc.
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