期刊
BIOTECHNOLOGY ADVANCES
卷 19, 期 6, 页码 451-485出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0734-9750(01)00077-5
关键词
scanning probe microscopy; force spectroscopy; biotechnology
Fifteen years after its invention, the scanning force microscope (SFM) is rooted deep in the biological sciences. Here we discuss the use of SFM in biotechnology and biomedical research. The spectrum of applications reviewed includes imaging, force spectroscopy and mapping, as well as sensor applications. It is our hope that this review will be useful for researchers considering the use of SFM in their studies but are uncertain about its scope of capabilities. For the benefit of readers unfamiliar with SFM technology, the fundamentals of SFM imaging and force measurement are also briefly introduced. (C) 2001 Elsevier Science Inc. All rights reserved.
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