期刊
JOURNAL OF BACTERIOLOGY
卷 183, 期 19, 页码 5718-5724出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.183.19.5718-5724.2001
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资金
- NIGMS NIH HHS [GM58213, GM55199, R01 GM058213] Funding Source: Medline
The absence of glycopeptidolipids (GPLs) abolishes the ability of mycobacteria both to slide over the surface of motility plates and to form biofilms on polyvinyl chloride. In a screen for biofilm-defective mutants of Mycobacterium smegmatis mc(2) 155, a new mutant was obtained that resulted in partial inhibition of both processes and also showed an intermediate rough colony morphology. The mariner transposon insertion mapped to a GPL biosynthesis gene (atf1) which encodes a putative acetyltranferase involved in the transfer of acetyl groups to the glycopeptide core. Physical characterization of the GPLs from the atf1 mutant demonstrated that they were not acetylated.
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