Immunological synapse formation is usually assumed to require antigen recognition by T cell receptors. However, the immunological synapse formed at the interface between naive T cells and dendritic cells (DCs) has never been described. We show here that in the absence of antigen, and even of major histocompatibility complex molecules,T cell-DC synapses are formed and lead to several T cell responses: a local increase in tyrosine phosphorylation, small Ca2+ responses, weak proliferation and long-term survival. These responses are triggered more readily in CD4(+)T cells than in CD8(+)T cells, which express a specific isoform of the repulsive molecule CD43. These phenomena may play a major role in the maintenance of the naive T cell pool in vivo.
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