期刊
JOURNAL OF VIROLOGY
卷 75, 期 20, 页码 9966-9976出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.20.9966-9976.2001
关键词
-
类别
资金
- NIAID NIH HHS [R01 AI033852, AI33852, AI30363, R21 AI030363, K08 AI 01638, R01 AI030363, R56 AI030363] Funding Source: Medline
- NIGMS NIH HHS [T32 GM07328] Funding Source: Medline
The murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is an important determinant of dissemination during primary infection. Reduced peak levels of viremia at day 5 were followed by reduced levels of virus in salivary glands starting at day 7 when mck insertion (RM461) and point (RM4511) mutants were compared to mck-expressing viruses. A dramatic MCK-2-enhanced inflammation occurred at the inoculation site over the first few days of infection, preceding viremia. The data further reinforce the role of MCK-2 as a proinflammatory signal that recruits leukocytes to increase the efficiency of viral dissemination in the host.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据