期刊
TRENDS IN CELL BIOLOGY
卷 11, 期 10, 页码 420-426出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(01)02091-8
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The COP9 signalosome is an evolutionarily conserved multiprotein complex that was first identified as an essential complex that represses light-regulated development in Arabidopsis. The COP9 signalosome has similarity to the lid of the 19S regulatory particle of the 26S proteasome and has recently been shown to interact with SCF-type E3 ubiquitin ligases. Although its precise role in the process of protein degradation remains to be established, the COP9 signalosome is a positive regulator of E3 ubiquitin ligases that functions at least in part by mediating the deconjugation of the NEDD8/RUB-modification from the cullin subunit of SCF-type E3 complexes. Here,we discuss these recent findings, which add an additional component to the biology of substrate-specific protein degradation.
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