期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 108, 期 4, 页码 S107-S110出版社
MOSBY-ELSEVIER
DOI: 10.1067/mai.2001.117820
关键词
superantigens; staphylococci; streptococci; enterotoxins; toxic shock syndrome; scarlet fever toxins; Kawasaki syndrome; atopic dermatitis; psoriasis
Pyrogenic toxin superantigens comprise a large family of exotoxins made by Staphylococcus aureus and group A streptococci. These toxins include toxic shock syndrome toxin-1, the staphylococcal enterotoxins, and the streptococcal pyrogenic exotoxins (synonyms: scarlet fever toxins and erythrogenic toxins), all of which have the ability to cause toxic shock syndromes and related illnesses. These toxins have a similar three-dimensional structure that allows them to interact with relatively invariant regions of major histocompatibility complex class II molecules on the surface of antigen-presenting cells and with certain variable regions of the T-cell receptor-beta chain. The consequence of these interactions (and other immunobiological properties of the toxins) is the exaggerated release of bioactive cytokines. The latter molecules are responsible for the clinical signs of illness associated with these toxins.
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