Solubilization and release properties of PEGylated diaminobutane poly(propylene imine) dendrimers

PEGylated diaminobutane poly(propylene imine) dendrimers were investigated as prospective drug delivery systems. Solubilization and release properties of these dendrimeric derivatives were investigated by fluorescence spectroscopy by employing pyrene as probe. The prospective application of the same dendrimers as drug carriers was first evaluated by incorporating within their interior sufficient concentrations of betamethasone corticosteroids. (C) 2001 Academic Press.