期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 49, 期 10, 页码 1362-1365出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.49.1362
关键词
pyrrolidine alkaloid; alpha-glucosidase inhibitor; Lobelia chinensis; Campanulaceae; radicamine A; radicamine B
Two new pyrrolidine alkaloids, radicamines A and B were isolated as inhibitors of alpha -glucosidase from Lobelia chinensis LOUR. (Campanulaceae). Radicamines A and B were formulated as (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(3-hydroxy-4-methoxyphenyl)-pyrrolidine (1) and (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(4-hydroxyphenyl)-pyrrolidine (2) on the basis of spectroscopic analyses and chemical methods.
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