期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 91, 期 4, 页码 1708-1712出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jappl.2001.91.4.1708
关键词
interleukin-4; interleukin-2; interleukin-6; interleukin-12; interferon-gamma
Prolonged strenuous exercise is followed by a temporary functional immune impairment. Low numbers of CD4(+) T helper (Th) and CD8(+) T cytotoxic (Tc) cells are found in the circulation. These cells can be divided according to their cytokine profile into type I (Th1 and Tc1), which produce interferon-gamma and interleukin (IL)-2, and type 2 (Th2 and Tc2) cells, which produce IL-4. The question addressed in the present study was whether exercise affected the relative balance between the circulating levels of these cytokine-producing T cells. Nine male runners performed treadmill running for 2.5 h at 75% of maximal oxygen consumption. The intracellular expression of cytokines was detected following stimulation with ionomycin and phorbol 12-myristate 13-acetate in blood obtained before, during, and after exercise. The percentage of type I T cells in the circulation was suppressed at the end of exercise and 2 h after exercise, whereas no changes were found in the percentage of type 2 T cells. Plasma epinephrine correlated negatively with the percentage of circulating CD8(+) T cells producing IL-2, whereas peak IL-6 correlated with the percentage of CD8(+) IL-4-producing T cells in the circulation. Peak plasma IL-6 correlated with plasma cortisol postrunning. In conclusion, the postexercise decrease in T lymphocyte number is accompanied by a more pronounced decrease in type 1 T cells, which may be linked to high plasma epinephrine. Furthermore, IL-6 may stimulate type 2 T cells, thereby maintaining a relatively unaltered percentage of these cells in the circulation compared with total circulating lymphocyte number.
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