期刊
ENVIRONMENTAL RESEARCH
卷 87, 期 2, 页码 57-68出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/enrs.2001.4292
关键词
lead; erythrocyte protoporphyrin; age; alcohol; smoking; cadmium; human blood pressure
The interrelationship of blood lead (BPb), activity of E-aminolevulinic acid dehydratase (ALAD), erythrocyte protoporphyrin (EP), blood cadmium (BCd), serum copper (SCu), serum zinc (SZn), serum selenium (SSe), hematocrit (Hct), body mass index (BMI), age, smoking habits, and alcohol consumption to blood pressure was examined in 154 Croatian male subjects 19-53 years of age. None of the subjects had been occupationally exposed to metals, or used any medication that could influence blood pressure or metal metabolism. The median and range values were: BPb, 57 (25-254) mug/L; ALAD, 51.9 (22.8-96.4) European units; EP, 0.68 (0.38-1.68) mu mol/L erythrocytes; BCd, 0.83 (0.21-11.93) mug/L; SCu, 1113 (763-1662) mug/L; SZn, 961 (734-1213) mug/L; SSe, 73.6 (44.2-106.9) mug/L; systolic blood pressure, 131 (105-165) mm Hg; and diastolic blood pressure, 94 (71-112) mm Hg. Systolic and diastolic blood pressure significantly correlated with an increase in BMI (P < 0.0005 and P < 0.0001, respectively), EP (P < 0.0002 and P < 0.002, respectively), and BPb (P < 0.005 and P < 0.01, respectively). After adjusting for potential confounding variables by multiple regression, an increase in systolic blood pressure was significantly predictive by BMI (P < 0.0005) and log BPb (P < 0.02) and inversely by log BPb * SSe interaction term (P < 0.007), or alternatively by EP (P < 0.0001), BMI (P < 0.001), alcohol (P < 0.02), and Het (P < 0.05). An increase in diastolic blood pressure was significantly predictive by BMI (P < 10(-5)), log BPb (P < 0.04), and alcohol (P = 0.05) and inversely by log BPb * SSe interaction term (P < 0.0007), or alternatively by BMI (P < 0.0001), EP (P < 0.002), alcohol (P < 0.004), and Hct (P < 0.04) and inversely by smoking (P < 0.04). With respect to the EP range in the study population, an increase of 27 mm Hg in systolic and 14 mm Hg in diastolic blood pressure was found. The study results indicate a significant Pb-related increase in blood pressure, particularly within the low-level Pb exposure range (BPb of 25-75 mug/L, and/or EP of 0.4-1.0 mu mol/L erythrocytes). (C) 2001 Academic Press.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据