期刊
AMERICAN JOURNAL OF PATHOLOGY
卷 159, 期 4, 页码 1405-1414出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0002-9440(10)62527-8
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Chemokine production by tumors is a well-known phenomenon, but its role in tumor biology remains debatable. Although intratumoral. injection of granulocyte chemotactic protein-2 (GCP-2) had no effect on tumor parameters, needle-free stable expression of the chemokine resulted in enhanced tumor growth. It is shown here that tumors that express a potent form of GCP-2 induce a strong influx and activation of tumor-associated neutrophils. The production of GCP-2 leads to intratumoral expression of gelatinase B and advantage for tumor growth by increased angiogenesis. These results are in line with the countercurrent principle of chemokine action and support the notion that paraneoplastic expression of ELR-positive CXC chemokines has to be blocked rather than stimulated in cancer therapy.
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