期刊
JOURNAL OF VIROLOGY
卷 75, 期 20, 页码 10000-10004出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.20.10000-10004.2001
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The human parechovirus 1 RGD motif in VP1 was studied by mutagenesis. An RGD-to-RGE change gave only revertant viruses with a restored RGD, while deletion of GD was lethal and nonrevertable. Mutations at the +1 and +2 positions had some effect on growth properties and a +1 M-to-P change was lethal. These studies indicate that the RGD motif plays a critical role in infectivity, presumably by interacting with integrins, and that downstream amino acids can have an influence on function.
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