期刊
BASIC RESEARCH IN CARDIOLOGY
卷 105, 期 5, 页码 597-608出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00395-010-0101-8
关键词
Beta-catenin; Hypertrophy; Intercalated disc; Canonical Wnt signalling; Dilated cardiomyopathy
资金
- Swiss National Science Foundation [3100-063486.00]
- Gebert Ruf Foundation [P038-01]
- Swiss Cardiovascular Training and Research Network (SCARTNet)
- Swiss University Conference (SUK)
- MRC
- Medical Research Council [G0400153] Funding Source: researchfish
- MRC [G0400153] Funding Source: UKRI
Beta-catenin is a component of the intercalated disc in cardiomyocytes, but can also be involved in signalling and activation of gene transcription. We wanted to determine how long-term changes in beta-catenin expression levels would affect mature cardiomyocytes. Conditional transgenic mice that either lacked beta-catenin or that expressed a non-degradable form of beta-catenin in the adult ventricle were created. While mice lacking beta-catenin in the ventricle do not have an overt phenotype, mice expressing a non-degradable form develop dilated cardiomyopathy and do not survive beyond 5 months. A detailed analysis could reveal that this phenotype is correlated with a distinct localisation of beta-catenin in adult cardiomyocytes, which cannot be detected in the nucleus, no matter how much protein is present. Our report is the first study that addresses long-term effects of either the absence of beta-catenin or its stabilisation on ventricular cardiomyocytes and it suggests that beta-catenin's role in the nucleus may be of little significance in the healthy adult heart.
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