期刊
NEUROBIOLOGY OF DISEASE
卷 8, 期 5, 页码 910-922出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/nbdi.2001.0425
关键词
neuronal plasticity; functional reorganization; cerebral ischemia; focal; repair; axonal sprouting
资金
- NINDS NIH HHS [NS37372, NS 28781, NS 17763] Funding Source: Medline
Cortical strokes alter functional maps but associated changes in connections have not been documented. The neuroanatomical tracer biotinylated dextran amine (BDA) was injected into cortex bordering infarcts 3 weeks after focal strokes in rat whisker barrel (somatosensory) cortex. The mirror locus in the opposite hemisphere was injected as a control. After 1 week of survival, brains were processed for cytochrome oxidase (CO)-, Nissi-, and BDA-labeled neurons. Cortex bordering the infarct (peri-infarct cortex) had abnormal CO and Nissl structure. BDA-labeled neurons were plotted and projections were analyzed quantitatively. Animals with small strokes had intracortical projections, arising from peri-infarct cortex, not seen in normal hemispheres: the overall orientation was statistically significantly different from and rotated 157 degrees relative to the controls. Compared to the controls, significantly fewer cells were labeled in the thalamus. Thus, after focal cortical stroke, the peri-infarct cortex is structurally abnormal, loses thalamic connections, and develops new horizontal cortical connections by axonal sprouting. (C) 2001 Academic Press.
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