期刊
CHEMICAL COMMUNICATIONS
卷 -, 期 19, 页码 1934-1935出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b106087m
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The first total synthesis of the trichlorinated natural product barbamide is described. The convergent approach involves coupling (S)-3-trichloromethylbutanoyl chloride with Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione) to give 15 followed by addition of the novel secondary amine N-methyl-(S)-dolaphenine 2 (prepared in 6 steps and 24% overall yield from N-CbZ-L-phenylalanine) to give the beta -keto amide 16 which was converted directly to the required (E)enol ether.
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