期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 11, 期 19, 页码 2647-2649出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(01)00524-8
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资金
- NHLBI NIH HHS [5 K14 HL03535] Funding Source: Medline
The reported diketopiperazine calpain inhibitor, cis-L-L-3.6-bis-(4-hydroxybenzyl)-1,4-dimethylpiperazine-2,5-dione 1, and its analogues 3 and 4 were synthesized from the corresponding amino acids. The previously assigned structure of 1 is confirmed but neither synthetic 1 nor its N-methylphenylalanine analogues 3 and 4 inhibit porcine erythrocyte calpain I. (C) 2001 Elsevier Science Ltd. All rights reserved.
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