期刊
NEUROLOGY
卷 57, 期 7, 页码 1313-1316出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.57.7.1313
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资金
- NCRR NIH HHS [RR00722] Funding Source: Medline
- NIAID NIH HHS [AI34668] Funding Source: Medline
- NINDS NIH HHS [NS32228] Funding Source: Medline
HIV-associated distal sensory polyneuropathy (DSP) is a common complication of AIDS. No effective treatment is available. The authors investigated the long-term effect (48 weeks) of the neurotrophin nerve growth factor (NGF) in an open-label study of 200 subjects with HIV-associated DSP. Similar to their previously reported double-blind study, the authors showed that NGF was safe and well tolerated and significantly improved pain symptoms. However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density.
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