期刊
SCIENCE
卷 294, 期 5541, 页码 380-382出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1062192
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资金
- NCI NIH HHS [CA33895] Funding Source: Medline
- NIDDK NIH HHS [DK09765] Funding Source: Medline
- NIGMS NIH HHS [GM58867-01] Funding Source: Medline
Poly-alpha2,8-sialic acid (PSA) has been implicated in numerous normal and pathological processes, including development, neuronal plasticity, and tumor metastasis. We report that cell surface PSA expression can be reversibly inhibited by a small molecule, N-butanoylmannosamine (ManBut). Inhibition occurs through a metabolic mechanism in which ManBut is converted to unnatural sialic acid derivatives that effectively act as chain terminators during cellular PSA biosynthesis. N-Propanoylmannosamine (ManProp), which differs from ManBut by a single methylene group, did not inhibit PSA biosynthesis. Modulation of PSA expression by chemical means has a rote complementary to genetic and biochemical approaches in the study of complex PSA-mediated events.
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