期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 191, 期 1-2, 页码 133-137出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0022-510X(01)00610-4
关键词
amyotrophic lateral sclerosis; physical exercise; physical activity; spasticity; fatigue; quality-of-life
The role of physical activity for patients with amyotrophic lateral sclerosis (ALS) is controversial. Twenty-five ALS patients were randomized to receive a moderate daily exercise program (n = 14) or not to perform any physical activity beyond their usual daily requirements (n = 11). At baseline and after 3, 6, 9 and 12 months, patients were assessed by manual muscle strength testing, the Ashworth spasticity scale, ALS functional rating scale (FRS), fatigue severity scale, a visual analogue scale for musculoskeletal pain and the quality-of-life scale (SF-36). At 3 months, patients who performed regular exercise showed less deterioration on FRS and Ashworth scales, but not on other parameters. At 6 months, there was no significant difference between groups, although a trend towards less deterioration in the treated,roup on most scales was observed. At 9 and 12 months, there were too few patients in each group for statistical evaluation. Our results show that a regular moderate physical exercise program has a short-lived positive effect on disability in ALS patients and should be recommended. (C) 2001 Elsevier Science B.V. All rights reserved.
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