期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 66, 期 2, 页码 155-162出版社
WILEY-LISS
DOI: 10.1002/jnr.1207
关键词
EAE; macrophages; Lovastatin; cytokines; CNS; statins
资金
- NINDS NIH HHS [NS-37766, NS-40810, NS-34741, NS-22576] Funding Source: Medline
Mononuclear cell infiltration into the CNS and induction of inflammatory cytokines and NOS in diseases like multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE) have been implicated in subsequent disease pathogenesis and progression. We report that Lovastatin treatment blocks the clinical disease and induction of inflammatory cytokines; and NOS in spinal cords of MBP induced EAE rats. A significant number of the infiltrating cells in CNS were ED1+ cells of monocyte/macrophage lineage. To understand the mechanism of efficacy of Lovastatin against EAE, we examined the effect of Lovastatin on the transmigration of mononuclear cells into EAE spinal cord. The data presented here documents that Lovastatin treatment attenuates the transmigration of mononuclear cells possibly by down regulating the expression of LFA-1, a ligand for ICAM, in endothelial-leukocyte interaction. These results indicate that Lovastatin treatment prevents infiltration by mononuclear cells into the CNS of rats induced for EAE, thereby lessening the histological changes and clinical signs and thus ameliorating the disease. These observations indicate that Lovastatin treatment may be of therapeutic value against inflammatory disease process associated with infiltration of activated mononuclear cells into the tissue. (C) 2001 Wiley-Liss, Inc.
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