期刊
JOURNAL OF INFECTIOUS DISEASES
卷 184, 期 8, 页码 1015-1021出版社
UNIV CHICAGO PRESS
DOI: 10.1086/323478
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资金
- NCRR NIH HHS [RR-00116] Funding Source: Medline
- NIMH NIH HHS [MH-61187] Funding Source: Medline
- NINDS NIH HHS [NS-35344, NS-36911, NS-35751] Funding Source: Medline
Macrophage chemoattractant protein-1 (MCP-1) may be a key trigger for the influx of macrophages into the brain in human immunodeficiency virus (HIV) encephalitis. In this study, simian immunodeficiency virus-infected macaques that developed moderate-to-severe encephalitis had significantly higher MCP-1 levels in cerebrospinal fluid (CSF) than in plasma as early as 28 days after inoculation, which was before the development of brain lesions. In contrast, CSF:plasma MCP-1 ratios remained constant at preinoculation levels in macaques that developed minimal or no encephalitis. Abundant MCP-1 protein and mRNA were detected in both macrophages and astrocytes in the brain. Macaques with increased MCP-1 in CSF had significantly greater expression of markers of macrophage and microglia activation and infiltration (CD68; P = .003) and astrocyte activation (glial fibrillary acidic protein; P = .019 and P = .031 and in white and gray matter, respectively). The results suggest that the CSF:plasma MCP-1 ratio may be a valuable prognostic marker for the development of HIV-induced central nervous system disease.
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