被撤回的出版物: Quercetin Decreases Liver Damage in Mice with Non-Alcoholic Steatohepatitis (Retracted article. See vol. 124, pg. 750, 2019)

Non-alcoholic steatohepatitis (NASH) is a frequent condition in obese patients that may progress to end-stage liver disease. This study was designed to evaluate the modulation of this condition by use of quercetin (Q), a flavonoid largely found in vegetable foods, with known anti-inflammatory and antioxidant properties, in the experimental model of non-alcoholic steatohepatitis (NASH) using a diet deficient in methionine and choline (MCD). Male C57BL6 mice were divided into four groups (n=16): (i) Control plus vehicle (control ration plus carboxymethylcellulose 1% used as vehicle, CO+V); (ii) Control ration plus Q 50mg/kg (CO+Q); (iii) MCD diet plus vehicle (NASH+V); and (iv) MCD diet plus Q (NASH+Q). Diets were administered for 4weeks. At the end of the experimental period, liver alterations, bioindicators of oxidative stress and DNA damage were assessed. NASH was diagnosed in 100% of the mice that were fed the MCD diet. In addition, a significant increase in DNA damage in liver tissue from NASH+V group was observed in comparison with CO+V. The group NASH+Q showed a significant decrease in hepatic damage enzymes, lipoperoxidation, DNA damage and a lower degree of macrovesicular steatosis, ballooning and inflammatory process. These findings suggest that Q may have protective effects by improving liver integrity in NASH.