期刊
ORGANIC LETTERS
卷 3, 期 21, 页码 3229-3232出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol0161108
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资金
- NCI NIH HHS [CA 80344, CA 31845, CA 31841] Funding Source: Medline
[GRAPHICS] Short oligomers of arginine function as remarkably efficient molecular transporters of drugs and probe molecules into cells and tissue. Currently, these compounds are prepared on resin through a unidirectional solid-phase synthesis. To extend the utility of these compounds for therapeutic and research applications, a scalable solution-phase synthesis of Arg(8) (1) has been developed on the basis of a segment doubling strategy that proceeds in 13 steps and 28% overall yield from 4, including a novel one-step perdeprotection-perguanidinylation reaction.
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