期刊
NEUROSCIENCE LETTERS
卷 312, 期 2, 页码 59-62出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)02184-X
关键词
metabotropic glutamate receptors; anti-peptide antibody; main olfactory bulb; accessory olfactory bulb; reciprocal synapse; periglomerular cell
The cellular localization of metabotropic glutamate receptors (mGluRs) (mGluR1 alpha, 2/3, 5a and 7) in the main and accessory olfactory bulb (MOB and AOB) of adult rats was compared by using affinity purified polyclonal antibodies directed to their C-termini. mGluR1 alpha and mGluR5a immunoreactivities were located in comparable structures of the MOB and AOB with different levels of intensity. mGluR5a reactivity was high in the AOB. mGluR2/3 showed a different pattern of expression in the MOB compared to that observed in the AOB; the periglomerular region of the MOB was strongly stained, but in the AOB it was the mitral/tufted cell layer that was intense. The mitral cell bodies in the MOB were strongly immunoreactive for mGluR7. These differences in the distribution of mGluRs in the MOB and AOB may reflect differences in synaptic transmission and sensitivity to neuromodulation in the two systems. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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