期刊
DEVELOPMENTAL BRAIN RESEARCH
卷 130, 期 2, 页码 217-230出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-3806(01)00239-5
关键词
DLX; PDZ; GRIP; transcription; homeodomain; basal ganglia
资金
- NIMH NIH HHS [K02 MH01046-01, R01 MH51561-01A1, R01 MH49428-01] Funding Source: Medline
The DLX homeodomain proteins control development of the basal ganglia and branchial arches. To identify co-factors that regulate DLX function we utilized the yeast two-hybrid assay, and found a DLX interacting protein (DIP2) which binds to the N-terminal region of DLX2 via a PDZ domain. DIP2 appears to be an alternatively spliced form of GRIP1, a protein known to bind AMPA glutamate receptors via PDZ domains. Thus, we named it GRIP1b. We provide evidence that GRIP1b can function as a transcriptional co-activator of DLX2 and DLX5. Glutamate receptors inhibit this co-activation. These results suggest that some PDZ proteins may regulate transcription via their interactions with homeodomain proteins. Furthermore, these results suggest a link between glutamate receptors, PDZ proteins and the DLX transcription factors, all of which are co-expressed in the developing basal ganglia. (C) 2001 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据