期刊
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
卷 102, 期 6, 页码 491-497出版社
WILEY
DOI: 10.1111/j.1742-7843.2008.00237.x
关键词
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资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM075857] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM075857, R01 GM075857] Funding Source: Medline
Norsolorinic acid, isolated from the Aspergillus nidulans, was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. To identity the anticancer mechanism of norsolorinic acid, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand. The results showed that norsolorinic acid induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that Fas/Fas ligand apoptotic system is the main pathway of norsolorinic acid-mediated apoptosis of MCF-7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of norsolorinic acid in MCF-7 cells.
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