期刊
NEUROREPORT
卷 12, 期 15, 页码 3217-3221出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200110290-00015
关键词
cell adhesion molecules; immunoglobulin super family; NCAM; neuron; neuronal differentiation; P19 embryonal carcinoma; retinoic acid
RA175, a new member of the immunoglobulin superfamily, is highly expressed during neuronal differentiation of P19 embryonal carcinoma cells. In situ hybridization showed that RA175 mRNA was detected in the developing nervous system, as well as the epithelium of the various non-neuronal tissues of mouse embryo. In contrast with the epithelia of the non-neuronal tissues, RA175 mRNA was not co-expressed with Sonic hedgehog mRNA and Patched mRNA during brain morphogenesis. RA175 mRNA was highly expressed in the anterior horn cells and the peripheral nervous system at embryonic day (E) 11.5 and in the central nervous system at E14.5-E18.5, but its expression decreased after birth and was undetectable in the adult mouse brain. NeuroReport 12:3217-3221 (C) 2001 Lippincott Williams & Wilkins.
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