期刊
NEUROREPORT
卷 12, 期 15, 页码 3349-3352出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200110290-00040
关键词
aging; cerebellum; classical eyeblink conditioning; delay paradigm; hippocampus; mice; trace paradigm
The age effect on classical eyeblink conditioning in unrestrained mice (C57BL/6J strain) was evaluated. Mice were trained at one of three age periods (8, 45-50 or 85-90 weeks). In the delay paradigm, significant learning deficits were evident in the 85-90 week-old group, but no deficits were observed in the behavior of the 45-50 week-old group. On the other hand, in the trace paradigm with a stimulus-free trace interval of 500 ms, significant deficits became apparent at the age of 45-50 weeks. These results indicate that trace eyeblink conditioning is more susceptible to age-related deterioration of memory in mice than delay eyeblink conditioning. NeuroReport 12:3349-3352 (C) 2001 Lippincott Williams & Wilkins.
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