期刊
NEUROREPORT
卷 12, 期 15, 页码 3371-3373出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200110290-00044
关键词
antioxidants; excitotoxicity; Huntington's disease; alpha-lipoic acid; transgenic mice
资金
- NIA NIH HHS [AG14390, AG12992] Funding Source: Medline
- NINDS NIH HHS [NS38180] Funding Source: Medline
There is substantial evidence implicating excitotoxicity and oxidative damage in the pathogenesis of Huntington's disease (HD). We therefore examined whether the antioxidants 2-sulpho-tert-phenylbutyinitrone (S-PBN) and alpha -lipoic acid could exert neuroprotective effects in transgenic mouse models of HD. S-PBN showed no effects on either weight loss or survival in the R6/2 transgenic HD mice. alpha -Lipoic acid produced significant increases in survival in both R6/2 and N171-82Q transgenic mouse models of HD. These findings suggest that alpha -lipoic acid might have beneficial effects in HD patients. NeuroReport 12:3371-3373 (C) 2001 Lippincott Williams & Wilkins.
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