期刊
CANCER LETTERS
卷 172, 期 2, 页码 193-198出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(01)00652-8
关键词
angiogenesis; anti-tumor activity; Maitake D-Fraction
类别
We have reported that D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities. The D-Fraction was observed to induce angiogenesis in vivo and to enhance the proliferation capability and migration capability of human vascular endothelial cell in vitro. The D-Fraction also increased plasma vascular endothelial growth factor (VEGF) concentration significantly. Also VEGF and TNF-alpha production by the activated peritoneal macrophages were enhanced. These results suggest that the anti-tumor activity of the D-Fraction is not only associated with the activation of the immuno-competent cells but also possibly related to the carcinoma angiogenesis induction. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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