期刊
CURRENT BIOLOGY
卷 11, 期 21, 页码 1706-1710出版社
CELL PRESS
DOI: 10.1016/S0960-9822(01)00526-7
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资金
- NIA NIH HHS [AG09909] Funding Source: Medline
An important quest in modern biology is to identify genes involved in aging. Model organisms such as the nematode Caenorhabditis elegans are particularly useful in this regard. The C. elegans genome has been sequenced [1], and single gene mutations that extend adult life span have been identified [2]. Among these longevity-controlling loci are four apparently unrelated genes that belong to the clk family [3-5]. In mammals, telomere length and structure can influence cellular, and possibly organismal, aging [6]. Here, we show that clk-2 encodes a regulator of telomere length in C. elegans.
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