期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 111, 期 2, 页码 151-155出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-0270(01)00450-2
关键词
nanoparticles; brain delivery; polycyanoacrylate; long-circulating systems; prion diseases
PEGylated polymeric nanoparticles are hereby presented as a potential efficient drug carrier for the delivery of active therapeutic molecules in prion experimental diseases. Based on their blood long-circulating characteristics, these PEGylated particles made by the amphiphilic copolymer poly [methoxy poly(ethylene glycol) cyanoacrylate-co-hexadecyl cyanoacrylate] (PEG-PHDCA), showed comparatively conventional non-PEGylated nanoparticles, a higher uptake by the spleen and the brain which are both the target tissues of PrPres accumulation in scrapie infected animals. (C) 2001 Published by Elsevier Science B.V.
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