期刊
RESPIRATION PHYSIOLOGY
卷 128, 期 2, 页码 235-240出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0034-5687(01)00303-6
关键词
arousal, hypoxia, age; development, arousal response, hypoxia; hypoxia, arousal; mammals, mouse; sleep, arousal
We examined the arousal response to 5% O-2 in newborn mice at several ages before and after peripheral chemoreceptor resetting namely, at 3, 12, and 48 h (n = 22 in each group). Breathing was measured by whole-body flow barometric plethysmography. Sleep and arousal were determined behaviourally. We found that: (1) the arousal response was present in all age groups: (2) the arousal response occurred during the hypoxic ventilatory decline in all age groups, showing that mechanoreceptor input was not sufficient to trigger arousal: and (3) arousal latency was shorter after than before chemoreceptor resetting, suggesting a contribution of chemoreceptors to arousal. We conclude that arousal may contribute to the hypoxic ventilatory response in the early postnatal period in mice and that it should be taken into consideration in studies of ventilatory control maturation in newborns. (C) 2001 Elsevier Science B.V. All rights reserved.
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