Effect of coriander seeds on hexachlorocyclohexane induced lipid peroxidation in rat liver

The effect of prefeeding of coriander seed powder (CSP) at 10% level on hexachlorocyclohexane (HCH) induced oxidative stress in rat liver was studied. The prefeeding of rats with CSP was found to reduce the HCH-induced rise in conjugated dienes, hydroperoxide and malondialdehyde (MDA) contents in liver. The intra peritonial injection of HCH reduced hepatic superoxide dismutase (SOD), catalase, glutathione S-transferase (GS-t), glucose-6-phosphate dehydrogenase (G-6-PDH) and glutathione reductase (GSSGR) activities in liver, where as the hepatic glutathione peroxidase (GSH-Px) and kidney gamma -glutamyltranspeptidase (GGT) activities were elevated. The prefeeding of CSP per se increased hepatic SOD, catalase, GS-t, G-6-PDH and GSSGR activities as well as in CSP prefed and then HCH-administered rats. The work shows the modulation of hepatic antioxidant system as a result of the prefeeding of CSP, which were otherwise reduced by HCH injection. The results reported here elicit the antioxidative effect of coriander seeds against HCH-induced formation of free radicals in rat liver. (C) 2001 Elsevier Science Inc. All rights reserved.