期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 134, 期 6, 页码 1190-1194出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjp.0704351
关键词
selective serotonin reuptake inhibitor; erectile dysfunction; nitric oxide
Increased incidence of impotence is associated with some selective scrotonin-reuptake-inhibitors (SSRIs), but the pathophysiological mechanism is unknown, Paroxetine and citalopram are extensively used SSRIs, but only paroxetine has been shown to inhibit nitric oxide synthase (NOS) activity. NO is a key mediator of penile erection. Thus, the aim of this study was to determine the effects of paroxetine and citalopram on erectile function and NO production, in a rat model. Application of cavernosal nerve electrical stimulation produced frequency-related intracavernosal pressure (ICP) increases, which were inhibited by the NOS inhibitor, N-G-nitro-L-arginine (0.3 mg kg(-1)). Acute or chronic (2 weeks) paroxetine-treatment (10 mg kg(-1)) reduced ICP-responses, while citalopram did not. Paroxetine, but not citalopram, significantly reduced nitrite+nitrate plasma levels by 61.4% and inhibited penile neuronal NOS (nNOS) protein expression by 31.2% after chronic treatment. The results show that paroxetine inhibits erectile responses in rats. We propose that this effect is due to reduced NO production and nNOS expression.
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