期刊
WORLD JOURNAL OF UROLOGY
卷 19, 期 5, 页码 365-370出版社
SPRINGER
DOI: 10.1007/PL00007104
关键词
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资金
- NCI NIH HHS [R01CA82677, CA09127] Funding Source: Medline
The TRAMP-C1 (C1) and TRAMP-C2 (C2) cell lines were derived from a prostate: tumor that arose in a mouse from the transgenic adenocarcinoma mouse prostate (TRAMP) model. However, their similarity to primary prostate tumors and therefore their usefulness in immunotherapy studies has not been clearly defined. We showed using RT-PCR that these cell lines exhibited a variety of prostate-specific genes expressed by human prostate tumors that may be used as tumor-associated antigens for immunotherapy. Interestingly, several of these genes are also expressed in cell lines that are not prostatic in origin. The prostate cell lines were also shown to grow in an androgen-independent manner, to be capable of expressing MHC class I and to be susceptible to specific lysis by cytotoxic T lymphocytes. Therefore, these cell lines will provide us with the ability to evaluate immune responses to and tolerance of prostate-specific protein peptides in an animal model.
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