期刊
MECHANISMS OF DEVELOPMENT
卷 109, 期 1, 页码 115-119出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(01)00518-4
关键词
semaphorin; vascular endothelial growth factor; angiogenesis; vasculogenesis; veins; arteries; endothelial cells; chick embryo; ephrin-B2; eph-B4
Neuropilin-1 (np1) and neuropilin-2 (np2) are receptors for class-3 semaphorins and for several isoforms of VEGF. We have cloned and characterized two chick isoforms of np2 cDNA. Expression patterns of npl, np2, and ephrin-B2 were compared in the developing vascular system of 24-72 h old chick embryos. We show for the first time that np2 is expressed in blood vessels in vivo from the earliest stages of their formation. In contrast to ephrin-B2, both np1 and np2 are expressed in blood islands of 24 h old chick embryos. At 48-72 h, npl expression is localized preferentially in arteries with an expression pattern that resembles that of ephrin-B2. In contrast, np2 is expressed preferentially in veins. Thus, neuropilins may play a role in determining the arterial or venous identity of blood vessels. (C) 2001 Elsevier Science Ltd. All rights reserved.
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