期刊
BIOLOGICAL PSYCHIATRY
卷 50, 期 9, 页码 677-684出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(01)01222-7
关键词
psychopathy; limbic system; functional magnetic resonance imaging; emotion; affect; amygdala; anterior cingulate
Background: Psychopathy is a complex personality disorder of unknown etiology. Central to the disorder are anomalies or difficulties in affective processing. Methods: Functional magnetic resonance imaging was used to elucidate the neurobiological correlates of these anomalies in criminal psychopaths during performance of an affective memory task. Results: Compared with criminal nonpsychopaths and noncriminal control participants, criminal psychopaths showed significantly less affect-related activity in the amygdala/hippocampal formation, parahippocampal gyrus, ventral striatum, and in the anterior and posterior cingulate gyri. Psychopathic criminals also showed evidence of overactivation in the bilateral fronto-temporal cortex for processing affective stimuli. Conclusions: These data suggest that the affective abnormalities so often observed in psychopathic offenders may be linked to deficient or weakened input from limbic structures. (C) 2001 Society of Biological Psychiatry.
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