期刊
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
卷 22, 期 9, 页码 901-911出版社
JAPAN ATHEROSCLEROSIS SOC
DOI: 10.5551/jat.28035
关键词
Cardio-ankle vascular index (CAVI); Vascular structure; Vascular function; Cardiovascular risk
资金
- Institute of Health Carlos III, ISCiii, of the Ministry of Economy and Competitiveness (Spain) through the Network for Prevention and Health Promotion in Primary Care (RedIAPP) [RD12/0005]
- ISCiii (FIS) [PI10/01088, PI10/02077, PI10/02043]
- European Union ERDF
- Autonomous Government of Castilla and Leon [GRS 635/A/11]
Aim: We assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the pulse wave velocity (PWV) and the central augmentation index (CAIx) that is independent of the subject's cardiovascular risk and pharmacological treatment. Methods: The CAVI score was measured in 500 subjects using a VaSera device and the brachial ankle PWV (ba-PWV) was calculated. A carotid ultrasound was used to measure the IMT. A Mobil-O-Graph device was used to measure the carotid femoral PWV (cf-PWV) and the CAIx. The Framingham- D'Agostino and SCORE scales were used to measure the subject's cardiovascular risk. Results: The mean value of the CAVI score was 8.59 +/- 1.1. IMT, CAIx and PWV maintained a positive association with the CAVI score (p< 0.01) in a multiple linear regression analysis, after adjusting for the subject's cardiovascular risk, body mass index and pharmacological treatment. The cut-off level that gave the maxima sensitivity and specificity to detect a mean IMT of > 0.90 mm was 8.95 (AUC=0.67) for the CAVI score, 8.85 (AUC=0.66) for cf-PWV and 15.10 (AUC=0.66) for ba-PWV. The cut-off to detect a maxima IMT of > 0.90 mm was 8.60 (AUC=0.62) for the CAVI score, 8.85 (AUC=0.64) for cf-PWV and 15.75 (AUC=0.70) for ba-PWV. Conclusion: There was a positive association of the CAVI score with vascular structure and function parameters that was independent of cardiovascular risk and any medications being used by the subject. The ability of the CAVI score to predict carotid atherosclerosis is similar to that of cf-PWV and ba-PWV in Caucasian adults.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据